(Answered) NR-565 Week 4 MidTerm Review. -Solved

COURSE  

NR-565: Advanced Pharmacology Fundamentals

  1. Question: G-Protien coupled receptors and how they interact with drugs
  2. Question: What neurotransmitters are excitatory?
  3. Question: Which is the most common CYP enzyme in the body? What role does it play?
  4. Question: What is the clinical significance of being an ultra-rapid CYP2D6 metabolizer?
  5. Question: What would be the concern if a drug is a CYP450indicer? How that might affect the metabolism of other drug the patient is taking?
  6. Question: Explain the significance of a drug being an inhibitor of P-glycoprotein? (see text)
  7. Question: Significance of a VCORC1 mutation for patients taking warfarin?
  8. Question: What out text has to say about National Standards of Culturally and Linguistically Appropriate Services?
  9. Question: What are some differences in drug metabolism in Asian populations?
  10. Question: According to out text and U.S office of Minority Healthy, what are reasons for poor health outcome among African American?
  11. Question: Which pharmacokinetic factors exhibit racial differences?
  12. Question: Phase I and II metabolism
  13. Question: What is the significance of VCORC1 mutation?
  14. Question: Can you describe how new drugs are developed from the text?
  15. Question: Explain what it means if a drug is an antagonist?
  16. Question: What the terms efficacy and bioavailability mean?
  17. Question: What are potential adverse effects associated with BBs according to the text? What lab abnormalities can occur?
  18. Question: Why do BBs, and clonidine require tapers when discontinuing them?
  19. Question: What are the effects of stimulation of beta 2 receptors?
  20. Question: Another concern of BBs is the risk of bronchospasm
  21. Question: Considering ACEIs: what labs require monitoring? What can happen to potassium levels? Are they safe for young women who could be pregnant?
  22. Question: Choose a topic from the study outline to discuss for your faculty response?
  23. Question: Choose a topic from the study outline to discuss for your faculty response?
  24. Question: Can you choose a topic from the study outline to discuss for your faculty response?
  25. Question: Can you choose a topic from the study outline to discuss for your faculty response?

ANSWER 

  1. G-Protien coupled receptors and how they interact with drugs

G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane, and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate the release of G proteins that can interact with various effector proteins to create physiological responses within the body (Insel & Sriram, 2018). This process occurs through secondary messengers (such as cAMP) which creates the extracellular interactions produced by the drug binding to the GRCP.

  1. What neurotransmitters are excitatory?

amino acids such as glycine, aspartate, and glutamate are excitatory (Woo & Robinson, p.16, 2016).……please click the icon below to purchase the midterm review at $19